Each guide with a different point count is not possible at the moment, I see how this could complicate simulation but I will see if this can be added. Depending on what you are trying to do, you can use the GenerateStrandData operator to modify the point count per guide using different conditions. Eg. Control the point count based on the length of the guide, or its curviness:
https://ephere.com/plugins/autodesk/maya/ornatrix/docs/2/Generate_Strand_Data.html
Jeordanis Figuereo (Product Designer. EPHERE Inc.)